Optic neuritis (on MRI)

Optic neuritis denotes inflammation of the optic nerve and is one of the more common causes of optic neuropathy. It can be thought of as broadly divided into infectious and non-infectious causes, although the latter is far more frequent When a patient presents with unilateral acute optic neuritis, one should obtain a brain MRI with and without gadolinium contrast in order to evaluate for other signs of central nervous system demyelinating disease, specifically multiple sclerosis Other tests to diagnose optic neuritis might include: Magnetic resonance imaging (MRI). An MRI scan uses a magnetic field and pulses of radio wave energy to make pictures of your body Optic neuritis occurs when swelling (inflammation) damages the optic nerve — a bundle of nerve fibers that transmits visual information from your eye to your brain. Common symptoms of optic neuritis include pain with eye movement and temporary vision loss in one eye

Restore Vision After Trauma - Clinically Proven Treatmen

All patients with Optic Neuritis should have a brain MRI because the occurrence of Optic Neuritis is a risk factor for the development of multiple sclerosis (MS) Optic neuritis is a pathology that is characterized by the course of the inflammatory process in the optic nerve and damage to its tissue and membrane. Two forms of the disease are distinguished - intrabulbar and retrobulbar 1) Normal MRI with the following features define extremely low MS-risk cohort (no MS cases at 15 years): painless optic neuritis, no light perception vision at onset, severe disc edema or disc hemorrhage, or macular star figure exudat The optic neuritis is seen in about one third of multiple sclerosis. Moreover, nearly 50% or greater (45- 80%) of patients with optic neuritis will develop multiple sclerosis within 15 years and the optic neuritis may be the only manifestation of multiple sclerosis Optic neuritis is a condition that affects the eye and your vision. It occurs when your optic nerve is inflamed. The optic nerve sends messages from your eyes to your brain so that you can interpret visual images. When the optic nerve is irritated and inflamed, it doesn't carry messages to the brain as well, and you can't see clearly

Optic neuritis Radiology Reference Article Radiopaedia

Optic neuritis (ON) is a common presenting symptom in pediatric CNS demyelinating disorders and may be associated with dramatic visual loss. Knowledge regarding clinical presentation, associated diseases, therapy, and outcomes in ON in children has grown over the past decade The 5-year risk of CDMS following optic neuritis is highly dependent on the number of lesions present on brain MRI. However, even a normal brain MRI does not preclude the development of CDMS. In these patients with no brain MRI lesions, certain clinical features identify a subgroup with a particularly low 5-year risk of CDMS

MRI is used routinely in the evaluation of patients when optic neuritis is the first demyelinating disease episode (Beck et al., 1993). Typically, the goal is to identify whether there is evidence of prior demyelinating episodes in the brain MRI showed diffuse thickening and irregularly outlined optic nerves of both eyes. Idiopathic bilateral optic neuritis in adults is a rare presentation. Prompt treatment with optic neuritis treatment trial (ONTT) improved the visual outcome

Optic Neuritis Fact Sheet Cleveland Clini

Optic Neuritis-MRI. Optic neuritis is defined as inflammation of the optic nerve. It is one of the causes of acute loss of vision associated with pain. Optic neuritis can be the initial episode for a patient who will subsequently develop multiple sclerosis. Thin fat-suppressed T2-weighted images, such as short tau inversion recovery sequences. ON is a clinical diagnosis, thus magnetic resonance imaging (MRI) of the brain and orbit with gadolinium is helpful to document optic nerve enhancement as well as demyelinating white matter lesions in the brain Optic Neuritis & MRI Questions. 02-04-2012, 07:18 PM. Hi everyone! I'm one of the lucky people living with possible MS, aka limbo land. I had one incident 2 years ago of tingling, numbness, weakness. I had a MRI and have 4 unidentified bright objects. A few months later I had symptoms again, this time bladder

Abstract Background: Optic neuritis is often the initial presentation of multiple sclerosis (MS). As established by the Optic Neuritis Treatment Trial, an abnormal baseline brain MRI is a strong predictor of MS after isolated optic neuritis in adults All patients with demyelinating optic neuritis should have a brain MRI scan, since those with a normal MRI, showing no evidence of other MS lesions at the time of an attack of optic neuritis, have a lower chance of going on to develop MS. Around 50-70 percent of patients with optic neuritis will have other MS lesions on an initial MRI The diagnosis of optic neuritis (inflammation of the optic nerve) is usually made clinically, with direct imaging of the optic nerves by magnetic resonance imaging (MRI) being reserved for atypical.. According to the Optic Neuritis Treatment Trial (Optic Neuritis Study Group, 2008), patients with no brain lesions on MRI had a 25% risk of progression to multiple sclerosis within 15 years, as compared to a 72% risk of progression in the same time period in patients with at least one demyelinating lesion seen on MRI Optic neuritis may occur as amanifestation of systemic autoimmune diseases, sarcoidosis, or central nervous system (CNS) demyelinating diseases. Chronic relapsing inflammatory optic neuropathy (CRION) is a recently described form of isolated recurrent optic neuropathy

Optic neuritis - Diagnosis and treatment - Mayo Clini

  1. Optic nerve inflammation may mimic tumor on MRI in the acute setting with nerve expansion, edema, and enhancement. Typically, findings are most apparent in the orbital segment of the nerve, which will be swollen with increased T2 signal (11). Contrast enhancement is best seen with fat-suppression techniques in the coronal plane
  2. Optic neuritis is a common symptom of multiple sclerosis (MS) that effects the eyes and your vision. Learn more from WebMD about the symptoms, causes, diagnosis, treatment, and complications of.
  3. e the sensitivity of orbital magnetic resonance imaging (MRI) in acute demyelinating optic neuritis (ON) in routine clinical practice, and the added value of a dedicated neuroradiology interpretation
  4. Optic neuritis is an inflammatory and demyelinating process that usually presents with monocular vision loss [3-4]. While there are many causes for optic neuritis, the demyelinating lesions seen in optic neuritis are similar to those that have been associated with multiple sclerosis. Patients are typically women between the ages of 20-40
  5. Background Optic perineuritis is an uncommon variety of orbital inflammatory disease that is distinct from demyelinating optic neuritis. Objective To describe the clinical and radiographic features of idiopathic optic perineuritis, with particular emphasis on those features that help to distinguish this condition from optic neuritis
  6. Optic neuritis is an inflammatory, demyelinating condition that causes acute, usually monocular, visual loss. It is highly associated with multiple sclerosis (MS). Optic neuritis is the presenting feature of MS in 15 to 20 percent of patients and occurs in 50 percent at some time during the course of their illness [ 1-4 ]

Optic neuritis - Symptoms and causes - Mayo Clini

  1. MRI brain lesions at presentation with optic neuritis (ON) increase the risk for developing clinically definite (CD) multiple sclerosis (MS). More detailed early MRI findings may improve prediction of conversion. The objectives of this study were to investigate the influence of number, location and activity of lesions at presentation, new.
  2. Use of MRI to differentiate optic neuritis and non-arteritic anterior ischemic optic neuropathy. Ophthalmology 2002 Sep; 109(9) : 1679 -84. Rizzo JF 3rd, Andreoli CM, Rabinov JD
  3. Clinical diagnosis: Thanks for the question: optic neuritis is a clinical diagnosis. Sometimes the radiologist can see inflammation and enhancement on MRI with specialized sequences and small field of view imaging (did you get an orbit mri?).We do not always see the abnormality on mri. The MRI may also have been to look for other lesions that can be associated with optic neuritis
  4. Stable effects after two weeks. Clinically proven, no surgery, no side effect
  5. People with optic neuritis who have a normal brain MRI scan have a relatively low risk of going on to develop MS, ranging from 8% to 25%, depending on the study. People with optic neuritis who have demyelination (also called spots, plaques, or lesions) on their brain MRI, have a much higher risk of developing MS, possibly as high as 80%
  6. New research by the Optic Neuritis Study Group has found that if magnetic resonance imaging (MRI) shows the presence of 1 or more white matter abnormalities (plaques) in patients with optic neuritis (ON), it is much more likely that those patients will develop multiple sclerosis (MS) in the next 10 years than ON patients with normal MRIs

Early MRI in optic neuritis: the risk for disability. Neurology. 2009 Feb 10. 72(6):542-50. . Seeger A, Schulze M, Schuettauf F, Ernemann U, Hauser TK. Advanced diffusion-weighted imaging in. MRI Scan to Diagnose Optic Neuritis MRI ( Magnetic Resonance Imaging) is a medical imaging technique highly efficient in visualization of internal structures of the body. The images of the desirable structures are obtained after a powerful magnetic field generated by the MRI machine aligns the magnetization of atoms in the parts of the body.

Background/methods: One hundred and fifteen patients with clinically isolated optic neuritis underwent magnetic resonance imaging (MRI) of the brain and spinal cord within 3 months of the onset of symptoms. Results: Eighty one (70%) patients had brain lesions and 31 (27%) had cord lesions. Cord lesions were seen in 12% with a normal brain MRI, 21% with between one and eight brain lesions, and. None of these patients had OCBs in the CSF and their MRI of the brain was normal. Out of 30 optic nerves, 19 imaged in these 15 patients showed abnormalities on MRI including thickening, high signal intensity, or enhancement. Myers et al. have described corticosteroid dependent optic neuritis, not associated with demyelinating disease. In their.

If lesions characteristic of multiple sclerosis (MS) are evident with magnetic resonance imaging (MRI), then immune-modulating therapies should be considered to delay subsequent attacks. Differential Diagnosis. The differential diagnosis of optic neuritis includes the following conditions: Inflammatory, demyelinating disease (classic Optic neuritis is an acute, inflammatory, demyelinating event of the optic nerve that may be idiopathic and localized to the optic nerve, or may be or become associated with other systemic illnesses--notably MS. Optic neuritis often is the initial presenting sign of MS. 1-3 After five years, clinically definite multiple sclerosis (CDMS.

The incidence of optic neuritis (ON, defined for this article as inflammatory demyelinating) is highest in populations located at higher latitudes (Northern United States; Northern and Western Europe; New Zealand and Southern Australia) compared with geographic locations closer to the equator. The brain MRI confirmed the presence of lesions. The evaluation would then be to order an MRI of the brain and orbit with administration of gadolinium to look for an enhancement of the optic nerve, which typically is present in optic neuritis. Optic neuritis is suspected in patients with characteristic pain and vision loss, particularly if they are young. Neuroimaging, preferably with gadolinium-enhanced MRI, is usually done and may show an enlarged, enhancing optic nerve MRI in optic neuritis. An MRI scan to look for white matter lesions is recommended for all patients pre-senting with any form of optic neu-ritis (Fig. 2). The volume of MRI white matter lesions predicts the risk of MS, and data on the value of steroids and interferons in reducing the risk of MS is valid only for patients with significant white mat Optic neuritis acute visual defect 3, 4, 6 th nerve palsy uveitis Face and Paranasal Sinuses Tumor Infection ENT tumor Sinus infection Trigeminal Neuralgia Neck Tumor Infection MRI NECK W AND W/O CONTRAST (UMC order appears as MRI FACE/ORBIT/NECK W & WO CONTRAST) 70543 Carotid/vertebral arterial disease AV

The findings of the ONTT, reported in more than 50 publications during the past 20 years, have numerous implications. Although the debate continues over the use of intravenous steroids in the management of acute optic neuritis to modify short-term risk of MS in patients with high-risk magnetic resonance imaging (MRI) results, there are other important evidence-based conclusions that make the. Optic neuritis can be seen as an inflammatory optic nerve lesion. Also, this disease includes nerve damage in demyelinating diseases. Within the framework of optical neuritis, intra and retrobulbar neuritis are distinguished, which differ significantly in the ophthalmoscopic picture A case of acute optic neuritis. A. 1.5 Tesla, contrast-enhanced spin echo T1-weighted, fat-suppressed coronal MRI through the orbits shows enlargement and contrast enhancement of the left optic nerve in the retrobulbar portion (arrow) MR Imaging Findings. A number of studies have used imaging techniques to investigate the anatomic changes of the ON in papilledema. 5,6,8,9,12 ⇓ ⇓ -15 Of the many imaging techniques, MR imaging has been of particular interest because of its ability to provide gross visualization of the optic globe, ON, orbits, and optic tract. Additionally, MR imaging provides higher soft-tissue contrast. In light of the MRI orbit findings, with normal CSF parameters, including negative oligoclonal bands, raised our suspicion of post-COVID-19 optic neuritis. She was started on a course of pulsed methylprednisolone for 5 days, and acetazolamide dose was increased to 500 mg BID

Studies have shown that 75% (3 out of 4) people with optic neuritis and additional brain abnormalities on MRI will develop MS within 15 years. In people who have a normal MRI at the time of their optic neuritis episode, 25% (1 out of 4) people will develop MS within 15 years MRI Scan of the orbits is used to evaluate masses either within the globe or behind it, complex infections, optic neuritis or causes of vision loss, thyroid opthalmopathy. MRI or magnetic resonance imaging creates detailed images of inside parts of our body by using strong magnetic fields and radio waves

MRI of the brain demonstrates abnormal enhancement of the left optic nerve (arrow), consistent with optic neuritis. MRI: magnetic resonance imaging. Graphic 69073 Version 3.0 If the MRI was negative at baseline, the risk of MS was 25% overall, and much lower for males and those with atypical presentations of optic neuritis. A single lesion doubled the 15-year risk to 50% Indeed, 10-year follow-up data from the ONTT indicated optic neuritis patients who demonstrate one or more white matter lesions on MRI have a 56% chance of developing clinically definite MS. Patients with no evidence of white matter disease had a 22% risk of developing MS in the same period.

Patient's Guide to Optic Neuritis - Brigham and Women's

Does Optic Neuritis Show Up On MRI & Can Eye Test Detect It

Optic Neuritis

Optic Neuritis - 2012 - American Academy of Ophthalmolog

Optic neuritis (multiple sclerosis) Radiology Case

Optic neuritis describes any condition that causes inflammation of the optic nerve; it may be associated with demyelinating diseases, or infectious or inflammatory processes. It is also known as optic papillitis (when the head of the optic nerve is involved), neuroretinitis when there is a combined involvement of optic disc and surrounding retina in the macular area and retrobulbar neuritis. The long-term objective of this investigation is to make it possible to more quickly and efficiently evaluate the efficacy of new drugs for the treatment of optic neuritis (ON) and multiple sclerosis (MS). The direct objective of this exploratory study is to determine if the unique properties of the.

Optic Neuritis Johns Hopkins Medicin

  1. Acute optic neuritis (ON) typically presents with ocular pain and low visual acuity (VA), and there is a risk of permanent vision loss if ON is not managed properly.1 ON may be the first symptom of inflammatory diseases of the central nervous system (CNS), such as multiple sclerosis and neuromyelitis optica spectrum disorder (NMOSD). Recently, we reported some distinct characteristics between.
  2. MRI allows confirmation of optic neuritis and assessment of prognosis as well as risk of multiple sclerosis in the future. Inflammation (contrast enhancement on the MRI) can be confirmed in 95% of patients with optic neuritis. Finding of brain lesions increases the chance of MS in the future
  3. Regular MRI scans can detect optic neuritis but offer no information on its severity and potential lasting consequences for a patient's vision. Currently in use clinically to detect and follow up on strokes, DTI uses a rapid series of MRI scans to track water diffusion in tissue. Noting that inflammation and the cell damage it causes would.
  4. Optic neuritis is typically monocular, meaning it affects one eye at a time, but it can affect both eyes sequentially or simultaneously. For some people, it may be an initial symptom of multiple sclerosis, a disease that causes inflammation and damage to nerves in the brain and spinal cord
  5. So first of all, the MRI features of anti-MOG optic neuritis are somewhat unique, and are one of the tools we can use to help distinguish typical optic neuritis from that associated with anti-MOG antibodies. One distinct feature is that anti-MOG optic neuritis often involves a long anterior portion of the optic nerve. So typically an orbital.
  6. Optic Neuritis is sometimes caused from MS, but not sure what else if you had a clean MRI (which detects MS). Blurred vision after exercise can be caused by MS also. From everything that I have seen on the net Lymes and MS mimick each other. But being that clean MRI and spinal, probably isn't MS. Lymes can show on an MRI also. Good Luck
  7. Optic neuritis and mri brain scan. New diagnosis and before diagnosis. Inactive_User 25 March 2021 18:24 #1. I had a bout if optic neuritis twice, once 3 months ago and one 2 weeks. The one 3 months was total loss of vision in my left eye only for a few hours and then healed itself

Get an MRI to check for nerve damage. If your doctor suspects MS could be the cause of your optic neuritis, they'll order an MRI, which will help them find areas of damage on your optic nerve and brain. If they find signs of nerve damage, they'll prescribe medication that can reduce the risk of developing multiple sclerosis MRI findings in optic neuritis. Brain MRI scans are abnormal in approximately 45% of patients at the onset, with percentages increasing later in the course of the disease (i.e., up to 77% of patients). The majority has bilateral lesions at onset and around one-third have sub-tentorial lesions, predominantly in the brainstem. Typically, lesions. Optic neuritis is a condition that affects the eye and your vision. It occurs when your optic nerve is inflamed. The optic nerve sends messages from your eyes to your brain so that you can interpret visual images. When the optic nerve is irritated and inflamed, it doesn't carry messages to the brain as well. You can't see clearly OPTIC NEURITIS (ON) - Myelitis Optic neuritis (ON) is an inflammatory demyelinating condition of the central nervous system that results in the loss of vision and is associated with eye pain, the real value of MRI in typical ON is not to image the optic nerves, but rather to image the. Brain magnetic resonance imaging (MRI) revealed bilateral swelling in the optic nerves on T1-weighted images (Figure 2(a)) and enhancement on gadolinium-enhanced T1-weighted and T1-weighted fat-suppressed images (Figures 2(b) and 2(c)), suggesting optic neuritis

Optic neuritis (ON) is a common first manifestation of multiple sclerosis (MS), and examination of patients with ON provides opportunities to study the early clinical stages of MS. This prospective study compares results of brain magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) examinations and HLA-Dw2 phenotyping in 60 consecutive patients with ON Optic Neuritis Your doctor thinks that you have had an episode of optic neuritis. This is the most common cause of sudden visual loss in a young patient. It is often associated with discomfort in or around the eye, An MRI scan can give us to give a rough guess as to the likelihood of recurrence Optic neuritis (On) is the presence of an acute inflammation of the optic nerve that results in painful loss of vision. it is the most commonly encountered optic neuropathy in general practice,1-4 and is often associated with multiple sclerosis (ms).3,4 studies show that in about 15-20% of m Background: - Optic neuritis often is a symptom of multiple sclerosis (MS). Many people who experience optic neuritis are later diagnosed with MS. MS disease activity seen on magnetic resonance imaging (MRI) scans is often greater than that seen in tests given during regular doctor's visits During optic neuritis attacks, orbital MRI (ideally acquired with coronal fat-suppressed T2- and post-contrast T1-weighted sequences) shows an extensive optic nerve T2 hyperintensity. This predominantly involves the anterior segments of the optic nerve, with almost routine inclusion of the intra-orbital segments, while chiasm and retro.

Pediatric optic neuritis Neurolog

Optic neuritis (ON) represents inflammation of the optic nerve. By far the most common form is idiopathic ON, which is a primary demyelinating disease occurring in isolation or as part of multiple sclerosis (MS). Ebers GC. Optic neuritis and multiple sclerosis OPTIC NEURITIS (ON) - Myelitis. Optic neuritis (ON) is an inflammatory demyelinating condition of the central nervous system that results in the loss of vision and is associated with eye pain, the real value of MRI in typical ON is not to image the optic nerves, but rather to image the Fetch This Document In individuals with optic neuritis, the threat of developing several sclerosis following one episode of optic neuritis has to do with 50 percent over a lifetime. Your risk of developing multiple sclerosis after optical neuritis enhances further if an MRI scan programs lesions on your brain The area of the eye that shows optic neuritis is the optic disc. This is the place on the retina (the back of the eye) where the optic nerve comes out. The lens is the clear, focusing part of the anterior eye behind the pupil. The iris is the anterior colored area that we see as blue eyes or brown eyes Optic Neuritis CPG v1 08062016 Disclaimer SEE ALSO: Acute Loss of Vision, Visual Field Loss, Multiple Sclerosis DESCRIPTION - Optic Neuritis (ON) is an acute inflammation of the optic nerve.It is traditionally divided into 'typical' and 'atypical' presentations

The 5-year risk of MS after optic neuritis Neurolog

People with optic neuritis who have a normal brain MRI scan have a relatively low risk of going on to develop MS, ranging from 8 percent to 25 percent, depending on the study. People with optic neuritis who have demyelination (spots, plaques or lesions) on their brain MRI, have a much higher risk of developing MS, possibly as high as 80 percent The investigation of acute optic neuritis: a review and proposed protocol. Nat Rev Neurol. 2014 Aug;10(8):447-58. Voss E et al. Clinical approach to optic neuritis: pitfalls, red flags and differential diagnosis Magnetic resonance imaging (MRI). An MRI scan uses a magnetic field and pulses of radio wave energy to make pictures of your body. During an MRI to check for optic neuritis, you might receive an injection of a contrast solution to make the optic nerve and other parts of your brain more visible on the images

Brain (2002), 125, 812±822 Contrast-enhanced MRI in acute optic neuritis: relationship to visual performance Mark J. Kupersmith,1,2 Therese Alban,2 Barbara Zeiffer2 and Daniel Lefton1 1INN at Beth Israel Medical Center and 2New York Eye Correspondence to: Mark J. Kupersmith, MD, INN at Beth and Ear In®rmary, New York, NY, USA Israel North 170 East End Avenue, New York, NY 10128, USA E-mail. However, similar to the adult population, the presence of white matter lesions on initial brain MRI is associated with a 27-fold increased risk of developing multiple sclerosis. 2 In addition, as the age at presentation of pediatric optic neuritis increases, the risk of developing multiple sclerosis increases by 32 percent per year. 2 Currently. Magnetic resonance imaging (MRI) scan. An MRI scan uses a magnetic field and pulses of radio wave energy to make pictures of your body. During an MRI to check for optic neuritis, you might receive an injection of a contrast solution to make the optic nerve and other parts of your brain more visible on the images Optic neuritis (ON) is when your optic nerve becomes inflamed, causing vision loss. Subscribe (OCT) or magnetic resonance imaging (MRI) to help reach the correct diagnosis


MRI ( figure 1) performed 5 days after the symptoms onset revealed high T2-weighted signal of the left optic nerve with evidence of diffusion restriction and apparent diffusion coefficient (ADC) reduction in the corresponding location. Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) view of left acute optic neuritis Optic neuritis (ON) is an inflammatory attack of the optic nerve that leads to visual disability. It is the most common optic neuropathy affecting healthy young adults, most commonly women aged 20-45 years. It can be idiopathic and monophasic or as part of a neurologic disease such as multiple sclerosis with recurrence and cumulative damage Beck RW, Arrington J, Murtagh FR, et al. Brain MRI in acute optic neuritis: experience of the Optic Neuritis Study Group. Arch Neurol. 1993;8:841-846. Optic Neuritis Study Group. The five-year risk of multiple sclerosis after optic neuritis. Experience of the Optic Neuritis Treatment Trial. Neurology. 1997;49:1404-1413 Optic nerve sheath dilatation or gadolinium-enhancement on magnetic resonance imaging in acute optic neuritis have been previously reported but have been thought to be rare occurrences. This study recruited 33 patients with acute unilateral optic neuritis Optic neuritis. Optic neuritis is the name for inflammation of the optic nerve. This is the nerve that carries messages from the eye to the brain. Although optic neuritis is associated with MS, not everyone who has optic neuritis will have, or go on to develop, MS. Many people will have optic neuritis with no further symptoms

Contrast‐enhanced MRI in acute optic neuritis

  1. Optic neuritis is the first sign of MS in about 15 to 20 percent of people who have MS. The lifetime risk of developing MS after an episode of optic neuritis is about 50 percent according to the.
  2. Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON) (COCON) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government
  3. Magnetic resonance imaging (MRI) of the brain and orbit revealed swelling of the retrobulbar intra-orbital segment of the optic nerve with a high T2 signal. A diagnosis of retrobulbar optic neuritis was made and patient was started on intravenous methylprednisolone for 3 days, followed by oral prednisolone for 14 days
Optic Neuritis-Causes-Symptoms-Signs-Treatment-PreventionOptic neuritis with marked distension of the optic nerveAxial T2WI illustrating the normal optic nerve anatomy and

Introduction. Optic neuritis (ON) is an acute inflammatory disorder of the optic nerve. The annual incidence of ON worldwide is 1-6.4 per 100,000 adults. 1-3 It is a common disease with various etiologies, including infectious and immune-mediated processes. 1 The present study focused mainly on immune-mediated ON. Multiple sclerosis-associated ON (MS-ON), or so-called typical ON, has. Optic neuritis, linked to inflammation and damage to the optic nerve, is among the vision problems of MS, but is usually mild, treatable and short-lasting. and an MRI scan (magnetic resonance. Demyelinating retrobulbar optic neuritis (ON) is an inflammatory condition that typically causes acute unilateral vision loss, relative afferent pupillary defect and pain with eye movement, with normal fundus examination. It is closely linked to multiple sclerosis (MS) and may be the first manifestation of this systemic disease